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July 2000 Cover
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A report in the Journal of Virology shows that a mutation in HIV-1 protease results in greater sensitivity to amprenavir in patients who are resistant to nelfinavir and indinavir. Researchers found that 6.4 percent of the
viruses were 2.5- to 12.5-fold more sensitive to amprenavir. The authors believe that the mutation could improve amprenavir binding.
The findings also show that phenotypic resistance testing is helpful in learning about multiple mutations and drug efficacy for HIV.
Editor's Note: from Reuters Health Info Services
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HIV Digest!
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