September 2000 Cover
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High doses of acyclovir given for a year could help lower the rate of AIDS-related non-Hodgkin's lymphoma, according to Dr. Ignatius Fong of the University of Toronto.
Dr. Fong and colleagues studied 29 AIDS patients with non-Hodgkin's lymphoma and 58 control subjects matched for age, sex, and duration of AIDS. The results revealed that 46.6 percent of control
subjects had used acyclovir at doses of 800/mg or more a day for a year, compared to 6.9 percent of the lymphoma patients, while 72.4 percent of patients with the lymphoma and 32.8 percent of the control subjects had never
taken acyclovir prior to developing lymphoma. The researchers concluded that high-dose acyclovir or ganciclovir/foscarnet given for at least 12 months is linked to protection against AIDS-related non-Hodgkin's lymphoma.
Editor's Note: from Reuters Health Info Services
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