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July 1999 Cover
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Many researchers are optimistic about HE2000, a new anti-AIDS drug produced by Hollis-Eden Pharmaceuticals. Three monkeys infected with virulent strains of
HIV were treated with HE2000, a synthetic version of the hormone DHEA. Although the drug did not completely eliminate the virus, the subjects lived twice as long as
those in the control group, gained weight, and had more energy. HE2000 appears to work by shutting down cellular proteins the virus requires to operate. Dr. Thomas
C. Merigan, the director of Stanford University's Center for AIDS research, explains that "if something works on the cell, not the virus, there is less pressure for the virus
to mutate and become resistant." Hollis-Eden is currently conducting human tests of the drug in the United States and South Africa.
Editor's Note: from Business Week
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