March 2003 Cover
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HOPS is an ongoing prospective observational cohort in which patients have been continuously recruited and followed up since 1992. The study assessed 5,672 HIV-1-infected patients
with a mean age of 42.6 for incidence of myocardial infarction.
During the observation period, 21 persons had a myocardial infarction. Nineteen of them were among the 3,247 patients taking protease inhibitors. Two were among the 2,425
patients who did not take the drugs. Researchers also documented 15 instances of angina, 11 among the 3,247 who took protease inhibitors, four among the other group. Data showed no
single protease inhibitor to be significantly more likely than the others to be associated with the incidence of myocardial infarction.
The authors noted that most patients who had a myocardial infarction or an angina episode also had other traditional risk factors, such as smoking, hypertension, hyperlipidemia (a
high concentration of lipids in the blood), and insulin resistance associated with diabetes mellitus.
Editor's Note: from the Lancet
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