October 2000 Cover
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Swiss researchers recently evaluated in vitro and in vivo evidence that mycophenolic acid (MPA), a selective inhibitor of the synthesis of guanosine nucleotides in lymphocytes, interferes with the life cycle of HIV
through immunological mechanisms. The scientists discovered that MPA affected CD4 and CD8 T cells, suppressing HIV infection.
This suggests that by targeting the cells which HIV attacks, a new therapy besides antiretroviral drugs could deter the virus. The researchers recommend that future studies of the effect of MPA and its
ester derivate mycophenolate mophetil on HIV-infected cells conducted, as this inhibitor could represent an alternative approach to highly active antiretroviral therapy.
Editor's Note: from Nature Medicine
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