April 2001 Cover
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A recent report suggests that individuals who take highly active antiretroviral therapy (HAART) during primary HIV infection see faster and more complete immune reconstitution than patients who start treatment later.
Researchers from St. Vincent's Hospital in Sydney, Australia, conducted a prospective study of 58 treatment-naive patients who were given indinavir or nelfinavir plus two nucleoside reverse transcriptase inhibitors. After one year, the median CD4 cell count in
the patients with primary HIV-1 infection rose from 470 to 758, while the median increase among the chronically infected patients was much smaller, from 204 to 310. The researchers also found that, compared to those with chronic infection, patients with primary
HIV-1 infection saw much larger increases in the number of naive and memory T cells.
Editor's Note: from AIDS
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