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January 2000 Cover
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Researchers have discovered that protease inhibitors used to fight HIV may cause changes that lead to heart disease. Dr. James Sosman of the University of
Wisconsin found that heart disease is a significant side effect of the drugs, which affect the endothelium, or the lining of the blood vessels. The researchers, who presented
their findings to a meeting of the American Heart Association, used ultrasound to image blood flow in the arteries of 21 HIV-infected patients who were taking
protease inhibitors. Compared to seven patients not taking the drugs, the endothelial linings of the protease patients were not functioning properly, the researchers said.
Editor's Note: from Reuters
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