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August 1999 Cover
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Castleman's Disease, a lymphatic hyperplasia, has two variants: hyaline vascular and the plasma cell type. In a letter to the editor, researchers from Ludwig
Maximilians University in Munich report that they observed a clustering of rapidly progressing multicentric Castleman's disease of the plasma-cell type. All of the patients had
HHV-8, while two had a history of Kaposi's sarcoma and a third had sarcomatoid Kaposi's sarcoma lesions. The authors assert that the clustering is unusual
because Castleman's is a rare disease and that the outbreak should be handled as a medical emergency. They also state that symptoms of Castleman's disease occurred
after highly active antiretroviral therapy was started. Investigators advise doctors treating HHV-8-positive patients with HAART to frequently monitor them for signs
of Castleman's disease.
Editor's Note: from the New England Journal of Medicine
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